Publications
2024
Tharp KM, Kersten K, Maller OM, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward M-K, Berestjuk I, ten Hoeve J, Samad B, Ironside AJ, Pasca di Magliano M, Muir A, Geiger R, Combes AJ & Weaver VM. Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment. Nature Cancer. 2024.
2023
Alvarez-Breckenridge C, Anderson KG, Correia AL, Demehri S, Dinh HQ, Dixon KO, Dunn GP, Evgin L, Goc J, Good Z, Hacohen N, Han P, Hanč P, Hickey J, Kersten K, Liu BC, Buque A, Miao Y', Milner JJ, Pritykin Y, Pucci F, Scharping NE, Sudmeier L, Wang Y, Wieland A, Williams MM. Lessons for the Next Generation of Scientists from the Second Annual Arthur and Sandra Irving Cancer Immunology Symposium. Cancer Immunology Research. 2023. 11(12):1571-1577.
Kersten K*, You R*, Liang S, Tharp KM, Pollack J, Weaver VM, Krummel MF & Headley MB. Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung. Cell Reports. 2023. 42(6):112582. *equal contribution
Blomberg OS, Kos K, Spagnuolo L, Isaeva OI, Garner H, Wellenstein MD, Bakker N, Duits DEM, Kersten K, Klarenbeek S, Hau CS, Kaldenbach D, Raeven EAM, Vrijland K, Kok M, de Visser KE. Neoadjuvant immune checkpoint blockade triggers persistent and systemic Treg activation which blunts therapeutic efficacy against metastatic spread of breast tumors. Oncoimmunology. 2023. 12(1):2201147.
Blomberg OS, Spagnuolo L, Garner H, Voorwerk L, Isaeva OI, van Dyck E, Bakker N, Chalabi M, Klaver C, Duijst M, Kersten K, Bruggeman M, Pastoors D, Hau C-S, Vrijland K, Raeven EAM, Kaldenbach D, Kos K, Beyaert R, Hoes L, Theelen WSME, Baas P, Voest EE, Wessels LFA, de Visser KE, Kok M. IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in advanced breast cancer. Cancer Cell. 2023. 41(1):106-123.
2022
Zimmerli D, Brambillasca CS, Talens F, Bhin J, Romanens L, Linstra R, Bhattacharya A, Joosten SEP, Da Silva AM, Padrao N, Wellenstein MD, Kersten K, de Boo M, Roorda M, Henneman L, de Bruijn R, Annunziato S, van der Burg E, Drenth AP, Lutz C, van de Ven M, Wessels LFA, de Visser KE, Zwart W, Fehrmann RSN, van Vugt MATM, Jonkers J. MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling. Nature Communications. 2022. 13(1):6579.
Kersten K, Hu KH, Combes AJ, Samad B, Harwin T, Ray A, Rao AA, Cai E, Marchuk K, Artichoker J, Courau T, Shi Q, Belk JA, Satpathy AT & Krummel MF. Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer. Cancer Cell. 2022. 40(6):624-638.
Highlighted in:
· Hochman P. Spatiotemporal co-dependency between macrophages and exhausted CD8+ T cells in cancer. Accelerating Cancer Immunotherapy Research (ACIR). June 2022. Weekly Digest Spotlight.
· Lubitz GS & Brody JD. Not just neighbors: positive feedback between tumour-associated macrophages and exhausted T cells. Nature Reviews Immunology, 2022. 22, 3. Pre-print Watch
2021
Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, Mills GB, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS, Cancer Target Discovery and Development Network (CTD2). An expanded universe of cancer targets. Cell. 2021. 184(5):1142-1155. * collaborator on CTD2 consortium.
2020
Hu KH, Eichorst JP, McGinnis CS, Patterson DM, Chow ED, Kersten K, Jameson SC, Gartner ZJ, Rao AA, Krummel MF. ZipSeq: barcoding for real-time mapping of single cell transcriptomes. Nature Methods. 2020 (8): 833-843.
Klarenbeek S, Doornebal CW, Kas SM, Bonzanni N, Bhin J, Braumuller TM, van der Heijden I, Opdam M, Schouten PC, Kersten K, de Bruijn R, Zingg D, Yemelyanenko J, Wessels LFA, de Visser KE, Jonkers J. Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system. Oncoimmunology. 2020. e1724049.
2019
Binnewies M, Mujal AM, Pollack JL, Combes AJ, Hardison EA, Barry KC, Tsui J, Ruhland MK, Kersten K, Abushawish MA, Spasic M, Giurintano JP, Chan V, Daud AI, Ha P, Ye CJ, Roberts EW, Krummel MF. Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Cell. 2019 177:556-571.
Salvagno C, Ciampricotti M, Tuit S, Hau CS, van Weverwijk A, Coffelt SB, Kersten K, Vrijland K, Kos K, Ulas T, Song JY, Ooi CH, Rüttinger D, Cassier PA, Jonkers J, Schultze JL, Ries CH, de Visser KE. Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response. Nature Cell Biology. 2019 21:511-521.
2018
Sobral-Leite M, Van de Vijver K, Michaut M, van der Linden R, Hooijer GKJ, Horlings HM, Severson TM, Mulligan AM, Weerasooriya N, Sanders J, Glas AM, Wehkamp D, Mittempergher L, Kersten K, Cimino-Mathews A, Peters D, Hooijberg E, Broeks A, van de Vijver MJ, Bernards R, Andrulis IL, Kok M, de Visser KE, Schmidt MK. Assessment of PD-L1 expression across breast cancer molecular subtypes, in relation to mutation rate, BRCA1-like status, tumor-infiltrating immune cells and survival. Oncoimmunology. 2018. 7:e1509820.
Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nature Medicine. 2018. 24:541-550.
2017
Kersten K, Coffelt SB, Hoogstraat M, Verstegen NJM, Vrijland K, Ciampricotti M, Doornebal CW, Hau CS, Wellenstein MD, Salvagno C, Doshi P, Lips EH, Wessels LFA, de Visser KE. Mammary tumor-derived CCL2 enhances pro-metastatic systemic inflammation through upregulation of IL1β in tumor-associated macrophages. Oncoimmunology. 2017. 6:e1334744.
Kersten K, de Visser KE, van Miltenburg MH, Jonkers J. Genetically engineered mouse models in oncology research and cancer medicine. EMBO Molecular Medicine. 2017. 9:137-153.
2015
Kersten K*, Salvagno C*, de Visser KE. Exploiting the Immunomodulatory Properties of Chemotherapeutic Drugs to Improve the Success of Cancer Immunotherapy. Frontiers in Immunology. 2015. 6:516. *equal contribution
Plaks V, Boldajipour B, Linnemann JR, Nguyen NH, Kersten K, Wolf Y, Casbon AJ, Kong N, van den Bijgaart RJ, Sheppard D, Melton AC, Krummel MF, Werb Z. Adaptive Immune Regulation of Mammary Postnatal Organogenesis. Developmental Cell. 2015. 34:493-504.
Coffelt SB, Kersten K*, Doornebal CW*, Weiden J, Vrijland K, Hau CS, Verstegen NJM, Ciampricotti M, Hawinkels LJAC, Jonkers J, de Visser KE. IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis. Nature. 2015. 522:345-348. *equal contribution